No. It relies on the backup camera that is located in the tailgate handle, which tracks a checkered sticker that must be placed quite specifically on the tongue of a standard bumper pull trailer.
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2017 Escape 5.0 TA
2015 Ford F150 Lariat 3.5L EcoBoost
2009 Escape 19 (previous)
“Most folks are about as happy as they make up their minds to be.” — Abraham Lincoln
In addition to the use of the tailgate camera, the system assumes that the hitch pivot point is just behind the bumper - not somewhere near the axle - so it wouldn't be tuned appropriately for the fifth-wheel configuration even if you relocated the camera.