The best and safest speed is the one that most of the traffic is doing. This results in less chance of conflict with other vehicles. Of course, when going too fast, it is not advisable, as on some freeways.
I always do at least the speed limit to be courteous to other drivers, and sometimes a bit over, but rarely any more than 10 kph. 120kph (75 kph) is the fastest I will do, even if traffic is going faster, as that is the fastest rated speed for my Goodyear Marathons, plus is the top of where I like to tow anyway.
Some of it depends on what I am towing with. My Pilot is more than adequate at towing, but really suffers in fuel economy, especially on hills, in the wind, or when going fast. The difference in fuel economy going from 100 to 120 is very noticeable. With the F-350 diesel, the difference is minimal as speed is increased, but it still does affect it. On average towing, the F-350 gets somewhat better fuel economy than the Pilot, but not towing the Pilot wins by a long shot.
Towing to Osoyoos and back home, I averaged just under 17 litres/100 km, which is near 17 miles/gal IMP, or 15 miles/gal US. This was doing anywhere from 90 to 120 kph for the most part, and through a few mountain ranges.
I yearn for the day when getting somewhere in good time is no longer an issue for me.
