Who said what would not work? The Escape wouldn't work with the Andersen Ultimate, the Andersen Ultimate wouldn't work with the rails, or the rails wouldn't work with the truck? There are a few links in this chain...
The coupler of the Andersen Ultimate system attaches to the pin and pinbox. This is an industry standard (Escape happens to be using a Lippert pinbox currently and used an Atwood pinbox previously, but it doesn't matter), so it will work with an Escape 5.0 (or 5.0TA).
The Andersen Ultimate hitch (ball and mounting frame) comes in two versions with different attachment systems. The one with four tabs on the bottom is designed to go into rails on the bed floor which are used by various brands of fifth-wheel hitch. Those rails are bolted - through the bed floor - into brackets which are attached to the frame. It doesn't matter whether you are using the Andersen Ultimate or a fifth-wheel hitch, the rails are the same so if it works for one it will work for the other.
Unfortunately, there are frame-to-rail bracket kits only for some models of truck, so not everyone can use this system easily. Fortunately, all brands of rails are interchangeable, so if one brand doesn't have brackets for your truck, another one might. Common brands include Reese, Curt, and Husky. Bracket kits are available for essentially all heavier-duty pickups ("3/4 ton" and "1 ton"), for most full-size "1/2 ton" pickups, and for only some mid-sized trucks.