The specially designed flat coax cable will usually insert only a very small signal loss into the system (less than a dB). For RG6 applications (such as the Weboost cell phone booster antenna), it would work well. It does not matter if the cable is going past metal, wood, or fiber glass. (Note: The flat coax is a specially designed product (see previous post for an example). Pounding a regular coax into a flat cable with just result in a dead coax.)
The nice benefit of the flat coax is that it is relatively cheap. It would allow one a low cost way to experiment with various setups and optimize their system (for example - where to put the antenna mast, how tall of a mast, etc). If a configuration proves to work well, then one may decide at that point to drill a hole in the trailer and make a more permanent install. (As you can tell, I am very hesitant to drill holes in the trailer until I am very, very confident on my design).
The one drawback is that some of these cables are more prone to damage than others. The amazon reviews and other sites can give insight into what cables hold up best.
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