go to
www.wigrr.com. You can order a FREE travel & visitors guide to the Great River Road of Wisconsin. It includes maps, sights, etc. The link has other links of area county visitor info.
Search key word of
Great River Road. There's probably tons of information available for other states along the way.
Those river towns are dang interesting. Some, stuck in time and shriveling up; others, vibrant, old and interesting.
It's a Big Muddy river. There's innumerable places beside it, along it's 2,340 miles of length. You are asking a
BIG question.
I have Wisconsin/Iowa suggestions. PM me for them.
bon voyage